Pantoprazole sodium sterile

April 29, 2022 by pharmavision0

Pantoprazole sodium sterile


Pantoprazole is a proton pump inhibitor (PPI) that is used to treat gastroesophageal reflux disease (GERD) and to protect the stomach. It’s also used in triple antibiotic regimens for the treatment of H. pylori infections, with medicines including amoxicillin, clarithromycin, and metronidazole. Long-term usage of PPIs has been linked to an increased risk of bacterial infections and decreased absorption of minerals including iron and B12.


Primary Characteristics:

A substituted sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl) methyl] sulfonyl] 1H-benzimidazole is the active component in PROTONIX® I.V. (pantoprazole sodium) for Injection. With a molecular weight of 405.4, its empirical formula is C16H14F2N3NaO4S. The rate of chemical breakdown in aqueous solution is pH-dependent and rises as pH decreases.




Pantoprazole injection is approved for the short-term (7-10 day) treatment of individuals with gastroesophageal reflux disease (GERD) with a history of erosive esophagitis. It is also used to treat pathological hyper secretory diseases such as Zollinger-Ellison Syndrome and other neoplastic illnesses. An extra 8-week course of therapy may be considered for adult patients who have not healed after 8 weeks of treatment.


Pantoprazole has been demonstrated to be more successful than histamine-2 receptor antagonists at reducing acid reflux symptoms, healing esophageal inflammation, and improving patient quality of life (H2 blockers). This medication has an outstanding safety record and a low rate of drug interactions. It is safe to use in a variety of high-risk patient populations, including the elderly and those with renal failure or mild hepatic impairment.


Mechanism of Action:

The production of hydrochloric acid (HCl) into the gastric lumen is primarily controlled by the proton pump’s H (+)/K (+)-ATPase, which is abundantly produced by stomach parietal cells. ATPase is an enzyme that enables hydrogen and potassium exchange inside the cell, resulting in potassium extrusion and the creation of HCl (gastric acid). Pantoprazole and other proton pump inhibitors are substituted Benz imidazole derivatives, which accumulate in the acidic region of a parietal cell before being converted to active sulfonamide derivatives.


Side Effects:

It is possible that you will get headaches or diarrhea. Redness, discomfort, or swelling at the injection site are also possible. Inform your doctor immediately away if you get persistent diarrhea, abdominal or stomach pain/cramping, fever, or blood/mucus in your stool. It is unusual to have a severe adverse response to this medication.


Before using pantoprazole, notify your doctor or pharmacist if you are allergic to it or any other medicines. This product may contain inactive chemicals that might cause allergic reactions or other issues. Consult your physician about strategies to prevent bone loss/fracture, such as taking calcium (such as calcium citrate) and vitamin D supplements.


Pantoprazole oral pill may produce an allergic response, which can lead to renal failure. The medication may raise a person’s risk of osteoporosis, a disorder in which bones grow brittle. It can reduce the quantity of magnesium in your body in persons who have low blood magnesium levels (hypomagnesemia). It can also generate false findings in neuroendocrine tumor tests.

For People with Osteoporosis:  Pantoprazole can raise a person’s risk of osteoporosis, a disorder in which bones become brittle. Inform your doctor if you have a family history of osteoporosis.

For people with low blood magnesium (hypo magnesium): Pantoprazole might cause a drop in magnesium levels in your body. If you have a history of hypomagnesemia, tell your doctor.

For People being tested for Neuroendocrine tumors: Pantoprazole can give false positives in these tests. As a result, your doctor will ask you to cease taking this medication at least 14 days before the testing. They may also request that you repeat the testing if necessary.


Vision Pharmaceuticals (PVT) Limited

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