Esomeprazole Sodium Sterile

April 29, 2022 by pharmavision0

Esomeprazole Sodium Sterile


Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD) and for gastric protection. It’s also used in quadruple regimens to treat H. pylori infections alongside antibiotics like Amoxicillin, Clarithromycin, and Metronidazole. Its effectiveness is comparable to that of other PPI medications like Omeprazole and Pantoprazole.

Primary Characteristics:

In vitro, esomeprazole and [DB00338] both inhibit acid secretion to a similar extent, with no significant differences between the two compounds. Long-term use of PPIs like this has been linked to side effects such as increased susceptibility to bacterial infections and decreased absorption of micronutrients like iron and B12.


Esomeprazole  used to treat acid reflux disorders such as erosive esophagitis healing and maintenance, symptomatic gastroesophageal reflux disease (GERD), peptic ulcer disease, H. pylori eradication, gastrointestinal bleed prevention with NSAID use, and long-term treatment of pathological hyper secretory conditions such as Zollinger-Ellison Syndrome.

Mechanism of Action:

Esomeprazole suppresses stomach acid by covalently binding to sulfhydryl groups of cysteine on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cells, preventing the final step in gastric acid production. Regardless of the stimulus, this effect inhibits both basal and stimulated gastric acid secretion. Because esomeprazole’s binding to the (H+, K+)-ATPase enzyme  irreversible and a new enzyme must expressed to resume acid secretion, the anti-allergic effect of esomeprazole lasts longer than 24 hours.


The s-isomer of Omeprazole, which is a race mate of the S- and R-enantiomers, is Esomeprazole. It prevents acid secretion into the gastric lumen by inhibiting ATPase at the gastric parietal cell’s secretory surface. This effect is dose-dependent, and regardless of the stimulus, it inhibits both basal and stimulated acid secretion. PPI use over time linked to side effects such as increased susceptibility to bacterial infections and decreased absorption of micronutrients like iron and B12.

Side Effects:

Blisters, peeling, or loosening of the skin are all possible side effects of this medication. You may not experience all of these side effects such as Fast heartbeat, dizziness, Darkened Urine, drowsiness, loss of appetite, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue etc., but if you do, you should seek medical help. If any of the following side effects persist or become bothersome, speak with your doctor. Unpleasant, unusual, or bad (after). In the stomach or bowels, there is too much air or gas. Hair loss or thinning  a condition in which the hair  lost or thinned.


To treat ulcers caused by H. pylori infection, this medicine  sometimes combined with amoxicillin (Amoxil) and clarithromycin (Biaxin). After using this medicine, consult your doctor if you experience a change in urination frequency or amount, fever, joint pain, loss of appetite, nausea, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or weight gain. This medication may increase your risk of hip, wrist, and spine fractures. This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely if you are over 50, take high doses, or take it for a year or more. If you have severe bone pain or swelling, call your doctor right away.


Vision Pharmaceuticals (PVT) Limited

Vision Pharmaceuticals are one of the best pharmaceuticals companies of the world. Different types of pharma products & drug pellets we manufacture speak volumes of the high quality, efficacy & durability. If you have any query or want to know about any product, contact us on following numbers.

+92 (051) 449 3587, +92 (51) 449 3589, +92 (321) 517 1779







Leave a Reply

Your email address will not be published. Required fields are marked *

Get in touch

Contact us now

Vision Pharmaceutical bulk manufacturing facilities ensure market competitive price without slightest compromise on quality

Contact Number

+92 (51) 4493589

Email Address

Follow us

Our Activity

Follow our social media pages activity for learning more about our services and products

Copyright by Vision Pharma. All rights reserved.

vision pharmapk logo