Vision Pharmaceutical with its unique and state of the art production and quality control techniques takes pride in unparalleled satisfaction of its end consumers through highest standard product portfolio and goal oriented business module. Here Quality control procedures are followed at every stage of production line and final product is bring under strict scrutiny.
Vision Pharmaceutical manufacture drug Pellets through its automated plant and evaluate them through various standardised technique. Only pellets that pass through these evaluation measures are allowed distribution to market.
We at Vision Pharmaceutical strive to keep our pellets shape uniform and in accordance with international standards. Prime requirements for successful coating is spherical and smooth shape of pellets. Both microscopic and non microscopic methods are used to determine Pellets’ shape. Pellet Shape affects its geometric properties, flow and compaction. It is possible to determine whether the pellet is spherical or asymmetrical. Spherical shaped pellets have minimum surface volume per unit area. The minimum face value is 6 for spherical shape Pellets, if the value exceeds 6 then the pellet is considered asymmetrical.
Pellet size is equally important factor in addition to shape. Pellet size is determined by sieve shaking method and microscopy. Vision Pharmaceutical commonly use sieve shaking method for evaluation of pellet size but microscopic measurements are also used whenever need arises.
Surface morphology is another very important parameter in pellets manufacturing. Scanning as well as analysis of cross section of pellets can be used to determine surface morphology. Microscopic properties of pellets, structure of pellets’ surface, density and frictional force between the pellets are parameters of utmost importance. Vision Pharmaceutical ensures to impart optimal morphological properties to its manufactured pellets in order to give these ,ideal compression, and disintegration properties.
Tensile strength is very important property of drug pellets. In order to evaluate the tensile strength of pellets, Vision Pharmaceutical uses tensile apparatus. Pellets are strained under five kg load cell until failure occur. Then tensile strength of that particular drug pellets is calculated by using various formula specifically devised by our quality control department.
The crushing strenght is the measure of load needed to break the pellet. We at Vision Pharmaceutical use material testing machine to measure crushing strenght of various drug Pellets. This process is repeated at every step of production line and at end product along with other quality control tests.
Specific Surface Area:
Surface per unit volume is called specific surface area. Size and shape of pellets is directly affected by this physical property alone. For film coating of pellets, knowledge of specific area is extremely important, but even for uncoated pellets it has got some importance. As this property directly influence drug release profile, so Vision Pharmaceutical production unit carefully monitor specific surface area of every individual batch of single or multi ingredient drug Pellets.
Disintegration time is very important characteristic for immediate release pellets. It can influence actual drug availability in vitro and peak plasma concentrations at various time intervals. Vision Pharmaceutical uses latest Disintegration Appartus to measure disintegration time of every batch of drug Pellets.